Yvonne S. Eisele, PhD
Assistant Professor of Medicine
Division of Cardiology
What question I’d like to answer
Yvonne received her undergraduate degree in Biology at the Carl von Ossietzky University in Oldenburg, Germany. She earned a PhD in Cellular and Molecular Neurobiology from the University of Tuebingen working in the laboratory of Dr. Mathias Jucker where she made seminal discoveries on prion-like aggregation of Abeta peptides in vivo that is now recognized as an important mechanism in Alzheimer’s disease. In 2013, she joined Dr. Jeffery Kelly’s laboratory at the Scripps Research Institute in San Diego, CA as a postdoc and focused on delineating the oligomer hypothesis of neurodegeneration in transthyretin-related amyloidosis. She has been the recipient of a number of awards including the Scholarship Award by the German National Academic Foundation (Studienstiftung des deutschen Volkes), the Young Investigator Award from the Association of German Alzheimer’s Disease Researchers and Physicians, a stipend from the German Academic Exchange Service (DAAD), and a NIA K99/R00 Pathway to Independence Award. Yvonne is a member of SfN (Society for Neuroscience), AHA (American Heart Association), ISTAART (International Society to Advance Alzheimer’s Research and Treatment), and serves as reviewer for various journals and funding agencies.
In 2018, Yvonne joined the University of Pittsburgh as an Assistant Professor of Medicine where her lab focuses on molecular mechanisms of Alzheimer’s disease and cardiac amyloidosis. Her passion is mentoring students and trainees in cutting edge research in a highly collaborative and supportive environment and advancing our understanding of these diseases.
Read more: Department of Medicine Faculty Profile
Masri A, Bukhari S, Eisele YS, Soman P. Molecular Imaging of Cardiac Amyloidosis. J Nucl Med. 2020 Jul;61(7):965-970. doi: 10.2967/jnumed.120.245381. Epub 2020 Jun 1. PMID: 32482792.
Eisele YS, Monteiro C, Fearns C, Encalada SE, Wiseman RL, Powers ET, Kelly JW. Targeting protein aggregation for the treatment of degenerative diseases. Nat Rev Drug Discov. 2015 Nov;14(11):759-80. doi: 10.1038/nrd4593. Epub 2015 Sep 4. PMID: 26338154; PMCID: PMC4628595.
Eisele YS, Obermüller U, Heilbronner G, Baumann F, Kaeser SA, Wolburg H, Walker LC, Staufenbiel M, Heikenwalder M, Jucker M. Peripherally applied Abeta-containing inoculates induce cerebral beta-amyloidosis. Science. 2010 Nov 12;330(6006):980-2. doi: 10.1126/science.1194516. Epub 2010 Oct 21. PMID: 20966215; PMCID: PMC3233904.
Eisele YS, Bolmont T, Heikenwalder M, Langer F, Jacobson LH, Yan ZX, Roth K, Aguzzi A, Staufenbiel M, Walker LC, Jucker M. Induction of cerebral beta-amyloidosis: intracerebral versus systemic Abeta inoculation. Proc Natl Acad Sci U S A. 2009 Aug 4;106(31):12926-31. doi: 10.1073/pnas.0903200106. Epub 2009 Jul 21. PMID: 19622727; PMCID: PMC2722323.
Eisele YS, Duyckaerts C. Propagation of Aß pathology: hypotheses, discoveries, and yet unresolved questions from experimental and human brain studies. Acta Neuropathol. 2016 Jan;131(1):5-25. doi: 10.1007/s00401-015-1516-y. Epub 2015 Dec 29. PMID: 26715565.
Current Lab Members
Danielle Moss, Research Technician
Julia Wiegers, Undergraduate Student Researcher