Shihui Liu, MD, PhD
Associate Professor of Medicine
Division of Infectious Diseases
Shihui Liu Lab
What question I’d like to answer
Shihui received his M.D. from Beijing Medical University (now Peking University Health Science Center). Shihui also obtained a M.S. in Infection and Immunity from the Beijing Institute of Microbiology and Epidemiology and a Ph.D. in Molecular Biology from the Beijing Institute of Biotechnology. After postdoctoral study at the National Institutes of Health, he became a Staff Scientist at the National Institute of Allergy and Infectious Diseases, NIH, in Bethesda Maryland. He moved to the Aging Institute at the University of Pittsburgh School of Medicine in 2018. Shihui is an Associate Professor of Medicine at the Division of Infectious Diseases, Department of Medicine.
Read more: Department of Medicine Faculty Profile
Liu S*, Bachran C, Gupta P, Miller-Randolph S, Wang H, Crown D, Zhang Y, Wein AN, Singh R, Fattah R, Leppla SH. Diphthamide modification on eukaryotic elongation factor 2 is needed to assure fidelity of mRNA translation and mouse development. Proc Natl Acad Sci U S A. 2012 Aug 21;109(34):13817-22. doi: 10.1073/pnas.1206933109. Epub 2012 Aug 6. PMID: 22869748; PMCID: PMC3427129.
Liu S*, Zhang Y, Moayeri M, Liu J, Crown D, Fattah RJ, Wein AN, Yu ZX, Finkel T, Leppla SH. Key tissue targets responsible for anthrax-toxin-induced lethality. Nature. 2013 Sep 5;501(7465):63-8. doi: 10.1038/nature12510. Epub 2013 Aug 28. PMID: 23995686; PMCID: PMC4080305.
Liu S*, Liu J, Ma Q, Cao L, Fattah RJ, Yu Z, Bugge TH, Finkel T, Leppla SH. Solid tumor therapy by selectively targeting stromal endothelial cells. Proc Natl Acad Sci U S A. 2016 Jul 12;113(28):E4079-87. doi: 10.1073/pnas.1600982113. Epub 2016 Jun 29. PMID: 27357689; PMCID: PMC4948345.
Liu J, Zuo Z, Sastalla I, Liu C, Jang JY, Sekine Y, Li Y, Pirooznia M, Leppla SH, Finkel T, Liu S*. Sequential CRISPR-Based Screens Identify LITAF and CDIP1 as the Bacillus cereus Hemolysin BL Toxin Host Receptors. Cell Host Microbe. 2020 Sep 9;28(3):402-410.e5. doi: 10.1016/j.chom.2020.05.012. Epub 2020 Jun 15. PMID: 32544461; PMCID: PMC7486266. (available on 2021-09-09).
Liu J, Zuo Z, Zou M, Finkel T, and Liu S*. Identification of the transcription factor Miz1 as an essential regulator of diphthamide biosynthesis using a CRISPR-mediated genome-wide screen. PLoS Genet. 2020 Oct 15;16(10):e1009068. doi: 10.1371/journal.pgen.1009068. PMID: 33057331; PMCID: PMC7591051.
Current Lab Members
Zhihao Sun, PhD, Postdoctoral Fellow
Michael C. Ewing, MS, Research Specialist