Yuan Liu, PhD
Division of Pulmonary, Allergy, and Critical Care Medicine
Our lab is interested in small molecule therapeutic development targeting ubiquitin-dependent protein degradation in age-related diseases.
Yuan Liu Lab
What question I’d like to answer
Yuan received her master’s degree in Genetics and her PhD from Nagoya University. After completing her postdoctoral training at the California Institute of Technology, Yuan joined the faculty at the University of Pittsburgh, in the Division of Pulmonary, Allergy and Critical Care Medicine (PACCM) in 2015. She joined the Aging Institute in 2018. Yuan serves on multiple editorial boards and grant review study sessions. Yuan is the co-founder of pharmaceutical startup company Generian.
Read more: Department of Medicine Faculty Profile
Lear T, Dunn SR, McKelvey AC, Mir A, Evankovich J, Chen BB, Liu Y. RING finger protein 113A regulates C-X-C chemokine receptor type 4 stability and signaling. Am J Physiol Cell Physiol. 2017 Nov 1;313(5):C584-C592. doi: 10.1152/ajpcell.00193.2017. Epub 2017 Oct 4. Erratum in: Am J Physiol Cell Physiol. 2019 Apr 1;316(4):C582. PMID: 28978524; PMCID: PMC5792167. (Corresponding author)
Liu Y, Lear TB, Verma M, Wang KZ, Otero PA, McKelvey AC, Dunn SR, Steer E, Bateman NW, Wu C, Jiang Y, Weathington NM, Rojas M, Chu CT, Chen BB, Mallampalli RK. Chemical inhibition of FBXO7 reduces inflammation and confers neuroprotection by stabilizing the mitochondrial kinase PINK1. JCI Insight. 2020 Jun 4;5(11):e131834. doi: 10.1172/jci.insight.131834. PMID: 32493843; PMCID: PMC7308049.
Chen Y, Evankovich JW, Lear TB, Tuncer F, Kennerdell JR, Camarco DP, Shishido MS, Liu Y, Chen BB. A small molecule NRF2 activator BC-1901S ameliorates inflammation through DCAF1/NRF2 axis. Redox Biol. 2020 May;32:101485. doi: 10.1016/j.redox.2020.101485. Epub 2020 Mar 4. PMID: 32171724; PMCID: PMC7068124. (Co-Corresponding author)
Liu Y, Jurczak MJ, Lear TB, Lin B, Larsen MB, Kennerdell JR, Chen Y, Huckestein BR, Nguyen MK, Tuncer F, Jiang Y, Monga SP, O’Donnell CP, Finkel T, Chen BB, Mallampalli RK. A Fbxo48 inhibitor prevents pAMPKα degradation and ameliorates insulin resistance. Nat Chem Biol. 2021 Mar;17(3):298-306. doi: 10.1038/s41589-020-00723-0. Epub 2021 Jan 25. PMID: 33495648. (Co-Corresponding author)
Chen Y, Lear TB, Evankovich JW, Larsen MB, Lin B, Alfaras I, Kennerdell JR, Salminen L, Camarco DP, Lockwood KC, Tuncer F, Liu J, Myerburg MM, McDyer JF, Liu Y, Finkel T, Chen BB. A high-throughput screen for TMPRSS2 expression identifies FDA-approved compounds that can limit SARS-CoV-2 entry. Nat Commun. 2021 Jun 23;12(1):3907. doi: 10.1038/s41467-021-24156-y. PMID: 34162861; PMCID: PMC8222394. (Co-Corresponding author)
Current Lab Members
Daniel Camarco, Research Associate