Andrey A Parkhitko, PhD
Assistant Professor of Medicine
Division of Endocrinology and Metabolism
Our lab is interested in how age-dependent metabolic changes can be targeted to extend health- and lifespan.
What question I’d like to answer
Andrey obtained his combined Bachelor, Master and Medical degree in Biochemistry and Molecular Biology at Russian State Medical University (RSMU), one of the premier medical schools in Russia. During his last year at RSMU, he was selected to work in the U.S. for one year in Dr. Henske’s laboratory at the Fox Chase Cancer Center, Philadelphia, PA. After completing his master’s thesis project, he was invited to continue his project at the Brigham and Women’s Hospital and Harvard Medical School in Boston, MA where Dr. Henske’s lab had moved. His Ph.D. thesis focused on the role of autophagy in the treatment of Tuberous Sclerosis Complex. For postdoctoral training, Andrey joined Dr. Norbert Perrimon’s lab, also at Harvard Medical School, to study how metabolism changes during aging in Drosophila, and how these changes could be targeted to extend lifespan and suppress age-dependent diseases. During his postdoctoral training, he was awarded the LAM Foundation Fellowship Award and the NIH Pathway to Independence Award (K99/R00). In 2020, Andrey was appointed to the rank of Assistant Professor at the Aging Institute at the University of Pittsburgh School of Medicine.
Read more: Department of Medicine Faculty Profile
Parkhitko AA, Ramesh D, Wang L, Leshchiner D, Filine E, Binari R, Olsen AL, Asara JM, Cracan V, Rabinowitz JD, Brockmann A, Perrimon N. Downregulation of the tyrosine degradation pathway extends Drosophila lifespan. Elife. 2020 Dec 15;9:e58053. doi: 10.7554/eLife.58053. PMID: 33319750; PMCID: PMC7744100.
Parkhitko AA, Binari R, Zhang N, Asara JM, Demontis F, Perrimon N. Tissue-specific down-regulation of S-adenosyl-homocysteine via suppression of dAhcyL1/dAhcyL2 extends health span and life span in Drosophila. Genes Dev. 2016 Jun 15;30(12):1409-22. doi: 10.1101/gad.282277.116. Epub 2016 Jun 16. PMID: 27313316; PMCID: PMC4926864.
Parkhitko AA, Jouandin P, Mohr SE, Perrimon N. Methionine metabolism and methyltransferases in the regulation of aging and lifespan extension across species. Aging Cell. 2019 Dec;18(6):e13034. doi: 10.1111/acel.13034. Epub 2019 Aug 28. PMID: 31460700; PMCID: PMC6826121.
Parkhitko AA, Filine E, Mohr SE, Moskalev A, Perrimon N. Targeting metabolic pathways for extension of lifespan and healthspan across multiple species. Ageing Res Rev. 2020 Dec;64:101188. doi: 10.1016/j.arr.2020.101188. Epub 2020 Oct 5. PMID: 33031925.
Parkhitko AA, Singh A, Hsieh S, Hu Y, Binari R, Lord CJ, Hannenhalli S, Ryan CJ, Perrimon N. Cross-species identification of PIP5K1-, splicing- and ubiquitin-related pathways as potential targets for RB1-deficient cells. PLoS Genet. 2021 Feb 16;17(2):e1009354. doi: 10.1371/journal.pgen.1009354. PMID: 33591981; PMCID: PMC7909629.
Current Lab Members
Farzdaq Al hammood, MB, Research Technician
Aidan Graham, Pitt Undergraduate Student
Maxwell A. Abom, Pitt Undergraduate Student
Palak S Mehta, Pitt Undergraduate Student