Matthew Steinhauser, MD
Associate Professor of Medicine
Division of Cardiology
Our lab is interested in molecular mechanisms of aging-related cardiometabolic diseases.
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For more information: https://www.steinhauserlab.com | https://chip.aging.pitt.edu/
Matthew completed his undergraduate and medical degree at the University of Michigan in Ann Arbor. He trained in Internal Medicine and was a Chief Resident at Columbia University Medical Center. He moved to Boston in 2006, where he completed a Cardiovascular Clinical Fellowship at the Brigham and Women’s Hospital, followed by postdoctoral research training in the laboratory of Dr. Richard Lee. Matthew started his laboratory in the Brigham and Women’s Hospital Division of Genetics in 2013. In 2019, he relocated the laboratory to the recently founded Aging Institute at the University of Pittsburgh School of Medicine. As part of his role in the Aging Institute, Matthew directs the newly founded Center for Human Integrative Physiology. He also sees patients with cardiovascular and metabolic diseases at UPMC Presbyterian Hospital.
Read more: Department of Medicine Faculty Profile
Kim SM, Lun M, Wang M, Senyo SE, Guillermier C, Patwari P, Steinhauser ML. Loss of white adipose hyperplastic potential is associated with enhanced susceptibility to insulin resistance. Cell Metab. 2014 Dec 2;20(6):1049-58. doi: 10.1016/j.cmet.2014.10.010. Epub 2014 Nov 20. PMID: 25456741; PMCID: PMC4715375.
Fazeli PK, Lun M, Kim SM, Bredella MA, Wright S, Zhang Y, Lee H, Catana C, Klibanski A, Patwari P, Steinhauser ML. FGF21 and the late adaptive response to starvation in humans. J Clin Invest. 2015 Nov 3;125(12):4601-11. doi: 10.1172/JCI83349. PMID: 26529252; PMCID: PMC4665770.
Zhang Y, Federation AJ, Kim S, O’Keefe JP, Lun M, Xiang D, Brown JD, Steinhauser ML. Targeting nuclear receptor NR4A1-dependent adipocyte progenitor quiescence promotes metabolic adaptation to obesity. J Clin Invest. 2018 Nov 1;128(11):4898-4911. doi: 10.1172/JCI98353. Epub 2018 Oct 2. PMID: 30277475; PMCID: PMC6205397.
Steinhauser ML, Bailey AP, Senyo SE, Guillermier C, Perlstein TS, Gould AP, Lee RT, Lechene CP. Multi-isotope imaging mass spectrometry quantifies stem cell division and metabolism. Nature. 2012 Jan 15;481(7382):516-9. doi: 10.1038/nature10734. PMID: 22246326; PMCID: PMC3267887.
Guillermier C, Fazeli PK, Kim S, Lun M, Zuflacht JP, Milian J, Lee H, Francois-Saint-Cyr H, Horreard F, Larson D, Rosen ED, Lee RT, Lechene CP, Steinhauser ML. Imaging mass spectrometry demonstrates age-related decline in human adipose plasticity. JCI Insight. 2017 Mar 9;2(5):e90349. doi: 10.1172/jci.insight.90349. PMID: 28289709; PMCID: PMC5333969.
Current Lab Members
Naveen Kumar, PhD – Post-doctoral Fellow
Tania Amorim, PhD – Post-doctoral Fellow
Natalie David, BS – Study Coordinator/Research Assistant