Assistant Professor of Cell Biology
The Tan lab studies cellular principles of aging and age-related pathology.
The Tan Lab studies core principles of cell biology in aging. Organelle stress and damages are common risk factors in aging and diseases. A major goal of our lab is elucidating the molecular mechanisms underlying the sensing, repairing, and clearance of damaged organelles in mammalian cells. We search for essential, unifying principles behind complex stress responses through unbiased approaches, and dissect underlying mechanisms with multidisciplinary methods including molecular biology, biochemistry, cell biology, and genetics. Current research topics include lysosomal quality control in aging and neurodegeneration, inter-organelle communications in cell homeostasis, and lysosomal stress in age-related inflammation.
What question I’d like to answer
Can we extend lifespan by stimulating cellular stress response pathways?
For more information: jaytanlab.org
Tan X, Thapa N, Sun Y, Anderson RA. A kinase independent role for EGF receptor in autophagy initiation. Cell. 2015;160(1-2):145-60.
Tan X, Sun Y, Thapa N, Liao Y, Hedman AC, Anderson RA. LAPTM4B is a PtdIns(4,5)P2 effector that regulates EGFR signaling, lysosomal sorting, and degradation. EMBO J. 2015; 34(4):475-90.
Tan X, Lambert PF, Rapraeger AC, Anderson RA. Stress-induced EGFR trafficking: mechanisms, functions, and therapeutic implications. Trends Cell Biol. 2016;26(5):352-66.
Tan X, Thapa N, Liao Y, Choi S, Anderson RA. PtdIns(4,5)P2 signaling regulates ATG14 and autophagy. PNAS. 2016;113(39):10896-901. doi: 10.1073/pnas.1523145113.
Tan X, Anderson RA. Keeping in touch with the ER network. Science. 2017;12;356(6338): 584-585.
Tan X, Sun L, Chen J, Chen ZJ. Detection of microbial infections through innate immune sensing of nucleic acids. Annual Review of Microbiology. 2018;72:447-78.
Gui X, Yang H, Li T, Tan X, Shi P, Du F, Chen ZJ. Autophagy Induction through STING Vesicle Trafficking Is a Primordial Function of the cGAS Pathway. Nature. 2019;567(7747):262-266.
Tan JX, Finkel T. Autophagy goes nuclear. Nature Cell Biology. 2020;22(10):1159-61.
Tan JX, Finkel T. Mitochondria as intracellular signaling platforms in health and disease. Journal of Cell Biology. 2020;219(5): e202002179.
Current Lab Members
Haoxiang Yang, BS, Research Assistant