Yusuke received his BS, Master and Ph.D. degree in Pharmaceutical Sciences from the University of Tokyo. Yusuke has focused his research career on the molecular and cellular biology of stress responses as a post-doctoral fellow and assistant professor in the Prof. Hidenori Ichijo Lab in Japan, a visiting researcher with Prof. David Ron lab at University of Cambridge in UK, and a research fellow at the National Institutes of Health in Bethesda, MD. He joined the faculty at the Aging Institute, University of Pittsburgh in October 2018.

Throughout his research career, Yusuke has been working on analyzing the molecular mechanisms underlying cellular responses to a variety of stresses including oxidative stress, proteo-toxic stress and metabolic stress. He has identified and characterized key molecules that play important roles in oxidative stress-induced cell death and immune responses using Drosophila genetic screens. Also, using somatic cell genetic approaches with CRISPR-Cas9 techniques, Yusuke uncovered a molecular target and a mechanism of action of the chemical inhibitor of the integrated stress response (ISR) that has been widely used in ISR focused research. Recently, his research group uncovered a novel stress response pathway activated by cellular metabolic stress.

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